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Date Published: 30/06/2025
Online Published: 30/06/2025
Abstract Views: 60
Views PDF: 26
Issue
Vol. 23 No. 2 (2025): Số 2 Tập 23 Năm 2025
Section
Science articles
How to Cite
Truong, T. T., Le, D. C., Tran, H., Bui, V. T., Le, T. L., & Tran, T. B. V. (2025). Development of quantitation method for Acyclovir in tablet of known manufacturing formula using Raman spectroscopy. Journal of Pharmacetical and Cosmetic Control, 23(2), 30-38. https://tapchikiemnghiem.vn/index.php/jpcc/article/view/57

Development of quantitation method for Acyclovir in tablet of known manufacturing formula using Raman spectroscopy

Thi Thuy Truong1, Dinh Chi Le2, Hoang Tran1, Van Trung Bui1, , Thi La Le1, Thi Bich Van Tran1
1 National Institute of Drug Quality Control
2 Ha Noi University of Pharmacy

Main Article Content

Abstract

A fast, simple, nondestructive method using Raman spectrometers was developed for quantitation of acyclovir (ACV) in tablet powder with known composition. The method employed spectra of reference mixture containing from 30% to 84% ACV (w/w) recorded in wavenumber region from 150 cm-1 to 2800 cm-1 to build PLS assay model using 4 factors. Raman spectra of the tabets were pre-processed in the wavebands of 320 cm-1 to 520 cm-1, 820 cm-1 to 900 cm-1 and 1000 cm-1 to 1200 cm-1 combined with partial least squares (PLS) regression to establish a quantitative model. The method was validated according to current international requirements on performance of analytical method, and was proven to have specificity, linearity, accuracy, and precision.

Article Details

Keywords

Acylovir, Raman spectroscopy, PLS

References

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